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KMID : 1139220220180010043
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Journal of Exercise Rehabilitation
2022 Volume.18 No. 1 p.43 ~ p.49
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Aerobic exercise is an independent determinant of levels of inflammation and oxidative stress in middle-aged obese females
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Park Kyung-Shin
Nickerson Brett S.
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Abstract
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The purpose of this study was to investigate the effects of a 4-week moderate-intensity aerobic exercise on changes of body composition and markers of inflammation and oxidative stress independent from weight loss in middle-aged obese females. Thity-five obese females were randomly assigned to either an exercise (EX, N = 16) or control (CON, N = 19) group. The EX performed moderate intensity aerobic exercise on the treadmill for 60 min at 55% of maximal oxygen consumption (VO2max) for 4 weeks (3 days/wk). Body composition measurement with dual-energy x-ray absorptiometry and blood collection were conducted before and after the 4-weeks intervention. Blood samples were used to measure levels of tumor necrosis factor-alpha (TNF-α), C-reactive protein, adiponectin, total antioxidant status (TAS), and 8-hydroxydeoxyguanosine. Four weeks of aerobic exercise intervention significantly increased VO2max in EX (P < 0.001). EX also observed a decrease in TNF-α (P = 0.033) and an increase in TAS (P = 0.028) without changes in body weight and fat mass after 4 weeks of aerobic exercise training. No changes were observed in CON after the intervention. Results of this study indicate that moderate aerobic exercises may contribute, at least a part, to reductions of inflammation and oxidative stress independently from fat loss. Therefore, it may reduce risks of obesity-associated disorders in middle-aged obese females.
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KEYWORD
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Aerobic exercise, Obesity, Body composition, Inflammatory cytokines, Oxidative stress
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